Nr. 3 - 3. Quartal 1996

Comparison of Tacrolimus and Steroids with a Cyclosporin A Based Immunosuppressive Regimen after Liver Transplantation - A Long Term Follow-Up

H. P. Lemmens, N. Raxes, S. Jonas, A. R. Müller, K. P. Platz, W. O. Bechstein, O. Guckelberger, P. Neuhaus

121 patients who took part in the European multicenter trial comparing tacrolimus and a cyclosporine-based quadrupel induction regimen as primary immunosuppression between 1990 and 1992 were followed up 36 to 50 months after liver transplantation. Both immunosuppressive protocols demonstrated good organ- and patient-survival with low rejection rates (5-year patient survival tacrolimus 82%, CsA 85%, 5-year organ survival tacrolimus 77%, CsA 75%). OKT3-resistant and chronic rejection episodes occurred less frequent under tacrolimus (1.6% vs. 11.7%). The incidence of infections, neuro-, and nephrotoxicity as well as de novo-malignancies was comparable in both groups.

Keywords:

Liver transplantation, immunosuppression, Tacrolimus

Kurztitel:

Lemmens, H. P. et al. (1996) TxMed 3:138

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