Nr. 2 - 2. Quartal 1994

Orthotopic Liver Xenotransplantation in the Baboon

B. Gridelli et al.

Liver xenotransplantation could overcome the dramatic shortage of cadaveric organs and prevent the reinfection of human liver grafts by B and C hepatitis viruses. In an experimental model of Vervet monkey to Chacma baboon liver xenotransplantation the characteristics of hepatic xenograft rejection and some elementary synthetic functions of the liver in the xenogeneic environment were studied. Extended survival after xenotransplantation was obtained with a cyclosporine-based immunosuppressive protocol. No major differences in the histology and immunopathology of allografts and xenografts were noted suggesting that the same immunologic mechanisms were operative. Liver xenografts supported the life of recipient baboons for over one year without overt metabolic defects.

Keywords:

Xenotransplantation, liver, cyclosporine, baboon

Kurztitel:

Gridelli, B. (1994) TxMed 2:148

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