Nr. 2 - 2. Quartal 1994

Investigations of Cellular Infection with Human Cytomegalovirus in Vitro: Activation and Suppression of the Cellular Immune Response

M. Scholz et al.

Considering the effect of cytomegalovirus-infection on the modulation of HLA class I and II antigens on endothelial cells, we established an infection model and present data from experiments dealing with lymphocyte activation a) following cytomegalovirus-infection, and b) following recognition of cytomegalovirus-infected cells in vitro. We found two conflicting tendencies. In some experiments the expression of the interleukin-2 receptor on lymphocytes was increased upon challenging with cytomegalovirus. Supernatants from these lymphocytes induced elevated expression of HLA class I on endothelial cells. Moreover, the latter effect was also observed when untreated lymphocytes were cocultured with syngeneic cytomegalovirus-infected endothelial cells. On the other hand, cytomegalovirus impaired the upregulation of the interleukin-2 receptor following mitogen stimulation of lymphocytes, and partly suppressed lymphocyte proliferation in mixed lymphocyte cultures.

Keywords:

Liver transplantation, CMV infection, HLA, endothelial cells, in vitro

Kurztitel:

Scholz, M. (1994) TxMed 2:72

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