CARDIOVASCULAR ENGINEERING Journal for Extracorporeal Circulation, Assist Devices,Transplantation and Artificial Organs
	Volume 4, 1999, No 1

Effect of ATP-Potassium Channel Opener Nicorandil on Long-term Cardiac Preservation
M. Hachida, H. Lu, A. Ohkado, H. Gu, X.-l. Zhang, H. Furukawa, T. Nakanishi, H. Koyanagi

Our data support the hypothesis that the ATP-sensitive potassium channel opener nicorandil can provide additional protection over hyperkalemic cardioplegia in long-term myocardial preservation. The property of nicorandil that inhibits intracellular calcium loading after a prolonged ischemia may contribute to the myocardial protective efficacy of this agent as an additive to conventional hyperkalemic cardioplegic solutions.

Key words: myocardial preservation, hyperkalemic cardioplegia, intracellular calcium loading

Address for Correspondence:
Prof. M. Hachida, M.D.
Dept. of Cardiovascular Surgery
The Heart Institute of Japan
Tokyo Women’s Med. College
8-1 Kawada, Shinjyuku
162 Tokyo
Japan

Reference:
(CVE. 1999; 4 (1): 18-22)

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