CARDIOVASCULAR
ENGINEERING
Journal for Extracorporeal Circulation, Assist Devices,Transplantation and Artificial Organs
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CARDIOVASCULAR
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Volume 3, 1998, No 2 |
Abstract:
Background: Cardiopulmonary bypass (CPB) induces a general
inflammatory reaction, at least partly caused by the release of
cytokines due to the contact of blood to foreign surfaces and
abnormal sheer forces. The present study comparatively evaluated
the effect of a roller and a centrifugal pump in the CPB system
on the release of pro- and anti-inflammatory cytokines. Methods:
60 patients undergoing coronary artery bypass grafting were
randomly assigned to two groups, receiving either a roller or a
centrifugal pump. Blood samples were taken at multiple time
points before, during and after CPB, and the plasma
concentrations of tumor necrosis factor-a (TNF-a), interferon g
(IFN g), interleukin (IL)-1ß, IL-2, IL-4, IL-6, IL-8 and IL-10
were analysed. For comparison of the two groups regarding
cytokine release, areas under curve were calculated. Results: IFN
g could not be detected in patients` plasma. The levels of IL-1ß
and IL-2 were close to the detection limit of the assays. The
concentrations of TNF-a, IL-4, IL-6, IL-8 and IL-10 peaked in the
late phase of CPB or early postoperatively. Cytokine release
during the investigated time period did not differ significantly
between the two groups. Conclusions: With the present operative
set-up, the release of cytokines during and following CPB cannot
be reduced by the use of a centrifugal pump in the CPB-circuit.
Keywords:
cardiopulmonary bypass, centrifugal pump, roller pump, cytokine
release
Address for Correspondence:
Reference:
(CVE. 1998; 3 (2): 89-91)
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