CARDIOVASCULAR ENGINEERING

CARDIOVASCULAR
ENGINEERING

Journal for Extracorporeal Circulation, Assist Devices,Transplantation and Artificial Organs

Volume 2, 1997, No 3



Remifentanil - A Review of Pharmacokinetics and Pharmacodynamics in Relation to Cardiac Anaesthesia

B. B. Poulton, D. J. R. Duthie

Abstract:
Remifentanil (3-(4-methoxycarbonyl-4-[(1-oxypropyl)-phenylamino]-1 piperidine, propanoic acid, methyl ester) is the first clinically useful esterase metabolised opioid. Its unique elimination properties give it a potentially useful role in cardiac anaesthesia where the haemodynamic stability observed with the use of conventional opiates is often associated with prolonged recovery times.

Keywords:
Remifentanil, esterase metabolised opioid, context sensitive half time, cardio-pulmonary bypass

Address for Correspondence:

B. B. Poulton
FRCA
Department of Anaesthesia
Papworth Hospital
Papworth Everard
Cambridge
CB3 8RE
United Kingdom

Reference:
(CVE. 1997; 2 (3): 174-176)


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