CARDIOVASCULAR ENGINEERING Journal for Extracorporeal Circulation, Assist Devices,Transplantation and Artificial Organs
	Volume 2, 1997, No 2

The Factors of Predicting Neurologic Functions on Brain Resuscitation - an Experimental Study in Rabbits

D. Ma, Y. Zhou, X. Xu, Q. Ma, J. Zhu, G. Shan, R. Xie

Abstract:
Background: On behalf of clinicians, patients, their families, and society, an early reliable prediction of the neurologic outcome of resuscitation patients is very important. The present study is aimed to find out the factors for predicting neurologic function on brain resuscitation using closed-thoracic cardiopulmonary bypass resuscitation in rabbits and thereby to guide clinical practice. Methods: Thirty-two New Zealand white rabbits were randomly divided into four groups and subjected to cardiac arrest times of 8, 10, 12 and 15 mins, respectively. Closed-thoracic cardiopulmonary bypass was used to resuscitate all hyperkalemia-induced cardiac arrested animals. During experiment, the recovery times of physiological indices were observed and at the end, neurologic deficit score (NDS) scale was used to evaluate neurologic function. Also plasma lactate and lipoperoxide concentrations were determined at given times during study. Results: Our data showed that NDS correlated well with the cardiac arrest time, EEG recovery time, logarithmic respiratory recovery time, logarithmic pupillary light reflex recovery time, logarithmic corneal reflex recovery time, logarithmic mechanical ventilation time and amounts of vasoconstrictor. NDS also correlated with blood pH values and plasma lactate concentrations at 90 mins post-resuscitation. Further statistical analysis discovered that the corneal reflex recovery time, EEG recovery time and pupillary light reflex recovery time are the first, second and third variables which correlated with other variables. There was no statistical relationship between NDS with lipoperoxide at any time after resuscitation and lactate at 5, 30, and 150 mins after resuscitation, as well as spontaneous circulatory recovery time and duration of CPB. Conclusion: During the early stage of resuscitation, some physio-biochemical indices can be regarded as indicators for evaluating neurologic status and prognosis after resuscitation. From this study, the most valuable indicators are corneal reflex, EEG and pupillary light reflex recovery time.

Keywords:
Neurologic prediction, cardiopulmonary-cerebral resuscitation, cardiopulmonary bypass, lactate, lipoperoxide, cardiac arrest

Address for Correspondence:

Reference:
(CVE. 1997; 2 (2): 138-144)

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