CARDIOVASCULAR ENGINEERING

CARDIOVASCULAR
ENGINEERING

Journal for Extracorporeal Circulation, Assist Devices,Transplantation and Artificial Organs

Volume 2, 1997, No 1



Cellular and Humoral Rejection after Cardiac Transplantation

M. L. Rose

Abstract:
The aetiology of cardiac transplant associated coronary artery disease can be visualised as consisting of two events: - Recognition and damage to allografted coronary endothelial cells by the immune system. - Activated or damaged endothelial cells resulting in intimal proliferation. The possibility that part of the pathology of chronic rejection includes an autoimmune component is not implausible.

Keywords:
cardiac transplantation, rejection, infiltration, MHC antigen, endothelial antigen, adhesion molecule, lymphocytotoxic antibody, non-lymphocytotoxic antibody, autoimmune response

Address for Correspondence:

Marlene Rose
Ph.D.
Transplant Immunology
National Heart and Lung Institute at Harefield Hospital
Harefield
Middlesex
UB9 6JH
UK

Reference:
(CVE. 1997; 2 (1): 19-33)


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