Christian Lehmann (Ed.)
2012, 120 pages,
Intravital imaging of the microcirculation represents a scientific
method bridging the gap between molecular microvascular research and
clinical studies. Imaging devices includes intravital microscopy (IVM)
and related technologies (e.g., Sidestream Dark-Field Imaging SDF).
Potential fields of research are inflammation, cancer angiogenesis,
arteriosclerosis and others. Recent IVM work showed that immune cell
responses to antigens in situ are different from those observed in vitro
and appear to be dictated by factors uniquely relevant to the
micro-environment of the intact organs. IVM can potentially generate new
discoveries and serve as a reality check for areas of research that
were formerly the exclusive domain of in vitro experimentation. Moreover,
using new generation intravital molecular imaging microscopy it is
possible for the first time to visualize directly specific pathological
processes and to explain more in detail pharmacological mechanisms.
Especially the SDF method provides the tools for translational research
from the bench to the bedside for a variety of organs. This book
describes intravital microcirculation imaging of the brain, liver,
intestine, joints, sublingual area and the eye. It is intended as a
compendium for preclinical and clinical microcirculatory experimentation.
It includes not only experimental techniques but also examples for
scientific projects that can be performed using the specific methods.
Therefore, it will be a valuable reference guide for basic researchers
as well as for clinical scientists.
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