2013, 580 pages,
price: 70,- Euro
The fourth edition will give a new, complete overview of the
therapeutic apheresis (TA) with all semi- and selective methods, which
are available. All methods, their functions, indications, clinical
results, criticisms, and future aspects are discussed. This edition
contains 580 pages including 117 tables, 85 figures, and 3380 references.
In 6 chapters historical highlights, methods of unselective,
semi-selective and selective separation procedures, complications, side
effects of TA, and clinical results of different diseases are mentioned.
Possible indications of TA are shown in pediatric diseases.
Semi-selective and selective separation methods such as
cascade-filtration, cryofiltration, plasmaperfusion,
fibrinogen-adsorption, different methods of Immunoadsorption,
LDL-apheresis, LDL hemoperfusion, and other methods, such as
BioLogic-DTPP-system, Molecular Adsorbent Recycling system (MARS),
Prometheus system etc., are discussed.
Therapeutic apheresis in organ transplantation is mentioned. TA in organ
transplantation offers new horizonts for ABO incompatible organ
transplantation. This is discussed for renal-, liver-, heart-, lung-,
and hematopoietic progenitor cell transplantation. The application of TA
in transplantation is a corner stone of several conditions in ABO
incompatible transplantation and enables to develop new strategies, the
best organ transplantation in patients even with a high degree of
immunonization or performed antibodies thereby expanding the use of
Different clinical application committees have made a gradation of
diseases, which are accepted for TA. All these new tendencies have
influenced the clinical routine of treatments. The advantages are the
elimination of pathologic substances and the interruption of pathogenic
reactions. The disadvantages are the unselective elimination of all
proteins by the unselective methods, the possible complications and the
high costs. The authors try to define with regard to the literature the
indications of different methods of TA. Especially in the present time,
in which the resources in the health systems decrease enormously, a
strong definition of indications for TA is necessary to save the health
of our patients and to reduce the costs in future.
This fourth edition should be a teaching and working book for all
physicians, nurses, scientists, and industries, who are interested in
this field. The experiments of modern biotechnologies to try a better
imitating of the organ functions will be more and more encouraging, and
we understand the pathophysiology of different diseases better and this
enable us a more effective therapy in patients with a bad prognosis.
Very important are various adsorption methods for plasma or blood of
various diseases. This edition will give answers to different questions
in this area.