K. Conrad, E.K.L. Chan, M.J. Fritzler, U. Sack, Y. Shoenfeld, A.S. Wiik (Eds.)
From Etiopathogenesis to the Prediction of Autoimmune Diseases: Relevance of Autoantibodies
Report on the 8th Dresden Symposium on Autoantibodies
held in Dresden on September 12-15, 2007
Chapter 1
Prediction of Autoimmune Diseases – Facts and Perspectives
Y. Shoenfeld: Prediction of autoimmunity – more than just autoantibodies
N. R. Rose: Predictive autoantibodies: Past, present and future
K. Conrad, W. Schößler, M. J. Fritzler: The predictive relevance of autoantibodies
Chapter 2
Induction of Autoantibodies
M. Fischer, A. Stoehr, J. V. Ravetch, M. Ehlers: The role of Toll-like receptors in the induction of autoantibodies and the development of autoimmune diseases
G. Steiner,M. Hoffmann, S. Hayer, R. Fritsch, J. Smolen: Autoimmune responses in experimental models of rheumatoid arthritis
E. Csernok, J. U. Holle, W. L. Gross: Origin of anti-neutrophil cytoplasmic antibodies (ANCA) – new insights
Chapter 3
Effects of Autoantigens and Autoantibodies
E. Toubi, Y. Shoenfeld: Protective autoantibodies: Role in homeostasis, clinical importance and therapeutic potential
M. Paltsev, A. Gabibov, S. Suchkov: Catalytic autoantibodies: Role in immune homeostasis and clinical autoimmunity
E. Tretyak, S. Suchkov: Catalytic autoantibodies in organ-specific autoimmunity: an update
P. von Landenberg, Y. Döring, M. D. Drechsler, N. Clemens, I. Obermeier, S. Bauer, J. Chapman, Y. Shoenfeld, M. Blank, K. J. Lackner: Antiphospholipid antibodies induce procoagulant cytokine activity stimulating the TLR8 pathway
M. Szyper Kravitz, Y. Shoenfeld: Clinical and pathological significance of autoantibodies against protectivemolecules
F. Hiepe, T. Dörner, R. Manz, A. Radbruch: Are autoantibodies secreted by long-lived plasma cells pathogenic?
M. Mediavilla-Varela, L. Sum Leoh, A. Basu, V. Ganapathy, C. A. Casiano: LEDGFp75/DFS70, a stress response autoantigen with multiple functions and broad clinical relevance
Chapter 4
Autoantibodies to Macromolecular Complexes
K. Ikeda, K. M. Pauley, A. Jakymiw, M. Satoh, M. J. Fritzler, E. K. L. Chan: Autoantibodies to key components of the RNA interference pathway
M. J. Fritzler, L. M. Stinton, E. K. L. Chan: Autoantibodies to cytoplasmic autoantigens in endosomes, exosomes and the Golgi Complex
M. Mahler, M. J. Fritzler: Novel aspects of autoantibodies to the human exosome (PM/Scl complex)
P. L. Meroni, M. Mondini, P. Airo, P. Riboldi, Y. Shoenfeld, M. Gariglio, S. Landolfo: The human interferon-inducible protein IFI16: a mediator of inflammation and a target for autoimmunity
Chapter 5
Receptors, Autoantibodies, and Disease
M. Fu: Autoimmunity and idiopathic dilated cardiomyopathy: Where we are?
G. Wallukat: Functional autoantibodies against G-protein coupled receptors
Chapter 6
Autoantibodies in Organ Specific Autoimmune Diseases
6.1
Neuromuscular and Neurological Diseases
B. Lang, A. Vincent: Pathogenic and diagnostic relevance of autoantibodies against ion channels
S. Bick, S. Altenkämper, I. Krasenbrink, M. Tschernatsch, A. Kirsten, F. Blaes, V. Fühlhuber: Surface-binding autoantibodies and B-cell activating factor (BAFF) in pediatric opsoclonus-myoclonus syndrome
R. Vitaliani, M. Zoccarato, S. Irani, S. Zanini, G. L. Gigli, B. Giometto, A.Vincent: Anti-neuropil antibody in a patient with limbic encephalitis and breast cancer
B. Giometto, M. Zoccarato, L. Zuliani, R. Vitaliani: Paraneoplastic limbic encephalitis with anti-Ma2 and CV2 antibodies
U. Wurster, J. Tümmler, E. Sindern, A. Borchert, M. Schilling: Long term survival of two patients with small cell lung carcinoma and anti-Hu antibodies. Relation to therapy and serial antibody determination
D. Saccomanno, G. P. Comi, N. Bresolin, M. Carpo: Possible implementation of diagnostic tools in paraneoplastic neurological disorders
T. Scheper, W. Meyer, P. Klatt, L. Komorowski, C. Probst, W. Schlumberger, W. Stöcker: EUROLINE neuronal antigens: A newly developed line immunoassay for the detection of antibodies against neuronal antigens in paraneoplastic syndromes
F. Blaes, D. Nascimento, K. Schmitz, O. Matz, M. Tschernatsch, M. Kaps: Complex regional pain syndrome and autoantibodies against differentiation-dependent neuronal surface antigens
I. Malbohan, L. Fialová, J. Svarcová, A. Bartos, P. Ridzon, R. Rusina: Antineurofilament antibodies in cerebrospinal fluid and serum in patients with amyotrophic lateral sclerosis
I. Malbohan, J. Svarcová, L. Fialová, A. Bartos: Avidity of antineurofilament antibodies determined by ELISA method
H. Schneider, K. Conrad, U. Canzler, T. Ziemssen, T. Talaska, D. Reinhold, R. L. Humbel, D. Roggenbuck: Anti-ganglioside autoantibody profiling in patients with autoimmune peripheral neuropathies by a new line immunoassay
P. W. Modderman, L. A. Aarden, R. Q. Hintzen, D. Hamann: Detection of anti-MOG autoantibodies in acute disseminated encephalomyelitis (ADEM) by FACS analysis using MOG-transfected LN18 cells
A. Lueking, C. Gutjahr, K. Schulte, V. Gruß, H. E. Meyer, C. Huels, S. Muellner, J. Beator: Discovery and validation of novel multiple sclerosis associated biomarkers using protein biochips
M. Carpo, D. Saccomanno, M. T. Bardella, S. Allaria, N. Bresolin, G. P. Comi: Neurological complications in celiac disease: Could have an autoimmune origin?
L. Laadhar, O. Sidhom, S. Masmoudi, M. Zitouni, M. Sellami-Kallel, H. Zouhei, S.Makni: Spectrum of autoantibodies in patients with psychiatric manifestations
6.2
Gastrointestinal and Liver Diseases
K. Malickova, P. L. Lakatos, R. Donoval, P. Sandova, I. Janatkova, M. Lukas: Anti-carbohydrate antibodies as new markers for inflammatory bowel disease
M. Franco, M. Ramalho, S. Alberto, L. Novais, G. de Sousa, J. Ramos de Deus: Differential diagnosis between Crohn’s disease vs non-CD patients using a combination of antiglycan antibodies (gASCA, ALCA, ACCA and AMCA)
M. Fabris, F. Barone, A. Lerussi, D. Visentini, A. Picierno, R. Maieron, D. Villalta. S. De Vita, N. Bizzaro, R. Tozzoli, S. Pizzolitto, J. Spencer, E. Tonutti: Aberrant expression of B cell-activating factor of the TNF family (BAFF) and its receptor in duodenal biopsies of patients with celiac disease
M. Fabris, A. Lerussi, F. Barone, J Spencer, D. Visentini, A. Picierno, R. Maieron, D. Villalta, F. Curcio, S. De Vita, N. Bizzaro, R. Tozzoli, E. Tonutti: Overexpression of B cell-activating factor of the TNF family (BAFF) in serum and duodenal biopsy in celiac disease patients
C. Prause, C. Probst, C. Dähnrich, W. Schlumberger, W. Stöcker, T. Richter, A. C. Hauer, M. Stern, H. Uhlig, M. W. Laass, K.-P. Zimmer, T. Mothes: Deamidated gliadin peptides are superior to native gliadin in ELISA for diagnosis of childhood celiac disease
M. Ritter, R. Lieske, T. Richter, A. C. Hauer, M. Stern, H. Uhlig, M. W. Laass, K.-P. Zimmer, T. Mothes: Antibodies against deamidated gliadin peptides as novel biomarkers of childhood celiac disease
L. Laadhar, F. Harzallah, A. Hassin, M. Zitouni, M. Kallel-Sellami, S. Masmoudi, H. Slimane, S. Makni: Screening for celiac disease in patients with Hashimoto thyroiditis
S. Stenman, K. Lindfors, I. R. Korponay-Szabo, O. Lohi, H.Wieser, M. Mäki, K. Kaukinen: Production of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits
E. Myrsky, K. Kaukinen, M. Syrjänen, I. R. Korponay-Szabo, M. Mäki, K.i Lindfors: Celiac disease-specific IgA class autoantibodies disturb angiogenesis
L. Komorowski, D. Bogdanos, C. Probst, C. Dähnrich, A. Rosemann, W. Schlumberger, W. Stöcker: Detection of primary biliary cirrhosis-associated anti-mitochondrial antibodies using an improved test system: Anti-M2/BPO ELISA
T. Martins, I. Abreu, C. Cardoso, A. Bastos, H. Trindade, J. Chaves: An help on primary biliary cirrhosis diagnostics? Comparison between a newly developed ELISA (PBC Screen) and the Sp100, gp210 ELISAs
W. Meyer, T. Scheper, N. Janssen, L. Komorowski, C. Probst, W. Schlumberger, D. Bogdanos, W. Stöcker: A comprehensive line immunoassay for the detection of autoantibodies in primary biliary cirrhosis (PBC)
6.3
Endocrine Diseases
E. Bonifacio, P. Achenbach: Autoantibody characteristics and combinations in the prediction of type 1 diabetes
M. Schlosser, W. Kerner, P. Achenbach, C. S. Hampe, R. Walther: Differentiation of type 1 diabetes risk by GAD antibody epitope analysis and insulin antibody affinity in antibody positive children from a general population
U. Walschus, I. Klöting, R. Walther, M. Schlosser: Examination of the diabetes-associated autoantigen GAD65 in serum as a possible early diagnostic marker of beta cell loss
6.4
Cutaneous Autoimmune Diseases
K. Mejri, M. Kallel-Sellami, L. Laadhar, H. Lahmer, M. Zitouni, S.Makni: Prevalence of autoantibodies in patients with pemphigus
R. Bailloud, J. Serratrice, S. Desplat-Jego, P. Thomas, P.-J. Weiller: Successful anti-CD20 therapy in paraneoplastic pemphigus associated with a follicular dendritic cell sarcoma
C. Probst, C. Dähnrich, L. Komorowski, I. M. Bloecker, E. Schmidt, W. Schlumberger, C. Sitaru, C. Rose, W. Stöcker, D. Zillikens: Sensitive and specific detection of pemphigoid autoantibodies by an Enzyme-linked immunosorbent assay using multimers of the NC16A domain of BP180 as antigen
Chapter 7
Autoantibodies in Systemic Autoimmune Diseases
J. G. Walker, C. Barnabe, M. J. Fritzler: Autoantibodies, classification criteria and diagnosis of systemic autoimmune rheumatic diseases
Y. Sherer, Y. Shoenfeld: Anti-phospholipid antibodies as predictors of autoimmune disease manifestations
7.1
Rheumatoid Arthritis and Other Arthropathies
J. J. B. C. van Beers, A. J. W. Zendman, W. J. van Venrooij, G. J. M. Pruijn: Citrullination in the arthritic synovium; the citrullinome, the antibodies against citrullinated proteins and their connection with RA pathogenesis
J. Rönnelid, M. Mullazehi, L. Mathsson: Differential prognostic impact of autoantibodies and inflammation markers in early rheumatoid arthritis
G. Serre: Clinical and pathophysiological relevance of the autoimmune response to citrullinated proteins
H. A. Menard, M. Lora, W. V. Giannobile, J. Mobley, D. Grenier, C. Bodet: Should rheumatoid patients have flossed more? Maybe…
P. Nicaise-Roland, S. Grootenboer-Mignot, A. Bruns, M. Hurtado, E. Palazzo, G. Hayem, O. Meyer, S. Chollet-Martin: Comparison of anti-mutated citrullinated vimentin antibodies with anti-CCP antibodies: Interest in RA diagnosis and during infliximab therapy
K. Conrad, B. Heschel, A. Thieme, R. Christoph, B. Roch, K. Lüthke, S. Bornstein, H.-E. Schröder: Improvement of serological RA diagnostics by autoantibody profiling
A. Konnopka, K. Conrad, C. Baerwald, H.-H. König: Cost effectiveness of autoantibodies against cyclic citrullinated peptide in the very early diagnosis of rheumatoid arthritis
C. Zimmermann, M. Tohidast-Akrad, P. Zenz, J. Smolen, G. Steiner: Characterization of cells expressing citrullinated proteins in synovial tissue of patients with rheumatoid arthritis, reactive arthritis, psoriatic arthritis and osteoarthritis
C. Duftner, C. Dejaco, H. J. Lakomek, M. Schirmer: Antibodies cross-reacting with a 28 kDa drosophila antigen for diagnosis of ankylosing spondylitis?
F. Hartig, R. Pechlaner: Hypothesis-testing for etiopathogenesis, therapy and prevention of ankylosing spondylitis, Klebsiella-reactive uveitis and rheumatoid arthritis
D. Kozakova, V. Bosak, E. Koskova, F. Mateicka: Autoantibody profile in slovak patients with juvenile idiopathic arthritis
7.2
SLE and Antiphospholipid Syndrome
L. Cebecauer, I. Lochman, V. Kral, R. W. Burlingame, W. Schlumberger: Antibodies against nucleosomes and DNA: Clinical and pathogenic significance
M. Spellerberg, M. Hayman, P. Chapman, L. Stamp, J. O’Donnell: Can anti-chromatin antibody ELISA replace FARR in a routine diagnostic laboratory?
C. Zimmermann, E. Hoefler, J. Smolen, G. Steiner: Evaluation of novel assay systems for the determination of autoantibodies to double-stranded DNA in patients with SLE
T. Lüttich, P. Eißfeller, C. Jauris, A. Kromminga: A novel dot assay for the detection of anti-dsDNA antibodies in SLE sera
G. Stummvoll, R. Fritsch, B. Meyer, M. Aringer, J. Smolen, G. Steiner: Characterization of cellular and humoral autoimmune responses to histone H1 and core histones in patients with SLE
S. Carujo, A. Belen Polonio, P. Munujos: Cryopreservation of crithidia luciliae
W. Schößler, D. Roggenbuck, T. Büttner, U. Kießling, H.-E. Schröder, K. Conrad: High sensitive detection of double-stranded DNA autoantibodies by a modified Crithidia luciliae immunofluorescence test (CLIFT)
P. Eißfeller, B. Pepperkok, T. Luettich, M. Mahler, C. Jauris, M. J. Fritzler: The association of anti-SS-A/Ro52 and anti-SS-A/Ro60 antibodies in different connective tissue diseases
A. W. Götz, F. Capuano, L. Pallavicini, K. Conrad, K. Tausche, H.-E. Schröder: Evaluation of novel chemiluminescence-based methods for the detection of anti-cardiolipin antibodies in APS and SLE patients
M. Tampoia, A. Ramunni, A. Zucano, P. Lisi, G. Pannarale, A. Fontana: Value of serum levels of autoantibodies for monitoring therapy with aphaeresis in antiphospholipid syndrome (APS)
7.3
Systemic Sclerosis
R. Tozzoli, G Kodermaz, N. Bizzaro, E. Tonutti, M. Tampoia, S. Platzgummer, A. Antico: Evaluation of an enzyme immunoassay for the detection of scleroderma-related autoantibodies
R. Tozzoli, G. Kodermaz, N. Bizzaro, E. Tonutti, M. Tampoia, S. Platzgummer, A. Antico, G. Morozzi, D. Bassetti: RNA polymerase III antibodies in patients with systemic sclerosis: Validation of a new ELISA method
S. Uibel, K. Hanke, C. Dähnrich, C. Brückner, K. Egerer, F. Hiepe, W. Schlumberger, G. Riemekasten: Anti-Scl70 antibody levels correlate with skin and organ fibrosis in patients with systemic sclerosis – analysis from the Charit´e SSc cohort
K. Hanke, S. Uibel, C. Brückner, C. Dähnrich, K. Egerer, F. Hiepe, W. Schlumberger, G. Riemekasten: Antibodies against CENP-B antigen identify a subset of systemic sclerosis patients with sicca syndrome and missing lung fibrosis – analysis of the Charit´e SSc cohort
7.4
ANCA-associated Vasculitis
F. Gioia, D. De Francesco: MPO and PR3 autoantibodies: Evaluation of a new indirect immunofluorescence method
B. Hellmich, E. Csernok, G. Fredenhagen, W. L. Gross: A novel ELISA detects anti-neutrophil cytoplasm antibodies against proteinase 3 with superior sensitivity
J. Damoiseaux, M. Buschtez, U. Steller, B. Zerbe, A. Rosemann, K. Fechner, W. Schlumberger, J. W. Cohen Tervaert, W. Stöcker: EUROPLUSTM ANCA BIOCHIP Mosaic: MPO and PR3 antigen dots improve the detection of ANCA by indirect immunofluorescence
J. Damoiseaux, C. Dähnrich, A. Rosemann, C. Probst, L. Komorowski, W. Schlumberger, E. Csernok, F. Hiepe, J. W. Cohen Tervaert: A newly developed ELISA using a mixture of native PR3 and recombinant PR3 expressed in human cells improves the serological investigation of ANCA-associated vasculitis
Chapter 8
Autoantibodies in Miscellaneous Diseases
I. Wichmann, I. Aguilera, A. J. Alvarez-Marquez, M. A. Gentil, A. Nunez-Roldan: Anti-GSTT1 antibody mediated chronic renal allograft rejection
N. Virstyuk, E. Cherkachuna: The antinuclear autoantibodies in patients with chronic heart failure
M. Cojocaru, I.M. Cojocaru, C. Burcin, A. Atanasiu: Determination of serum anti-S100 autoantibodies in patients with acute ischemic stroke
K. Nkana, F. Lachenal, R. N. Josserand, I. Durieu, N. Fabien: Prevalence and clinical significance of autoantibodies in 147 adult patients with cystic fibrosis
A. M. Rouquette, S. Obadia, P. M’Bappe, I. Hagege, F. Boussa-Khettab, L.Tshilolo, R. Girot: High prevalence of autoantibodies in patients with sickle cell disease
Chapter 9
Methodical Aspects and Diagnostic Strategies
A. Wiik: Strategies and algorithms to improve the early diagnosis of autoimmune rheumatic diseases
S. H. Barbosa, D. Mesquita Junior, P. Guilherme Leser, A. Dellavance, L. E. Coelho Andrade: Autoantibodies in individuals with no apparent autoimmune disease
R. Tozzoli, D. Giavarina, D. Villalta, N. Bizzaro: Definition of reference intervals in autoantibody assays using indirect methods based on current data
A. Kromminga: Lessons from autoantibody binding avidity
9.1
Identification of Novel Autoantibodies
A. Lueking, A. Kowald, H. E. Meyer, J. Beator: Systematic development of antibody profiles as biomarkers
C. Hempp, F. Haag, F. Koch-Nolte, T. Krieger: Identification of two new autoantigens in patients with high titres of antinuclear autoantibodies using protein macro-array technology
A. Kowald: Protein arrays as versatile tool for the characterization of antibodies
K. G. Ronquist, L. Carlsson, G. Ronquist, A. Larsson: Anti-prostasome autoantibodies in serum of prostate cancer patients
S. C. Joachim, J. Reichelt, S. Berneiser, N. Pfeiffer, F. H. Grus: Autoantibodies in patients with glaucoma
9.2
Multiplex Assays for Autoantibody Analyses
A. M. C. Lokate, J. B. Beusink, R. B. M. Schasfoort, G. J. M. Pruijn: Proteomics on a chip for monitoring autoimmune diseases
U. Klause, M. Rothfuss, H. Eberl, M. Wanger, A. Nichtl, H.-J.Müller, B. Risse: Development of a novel multi-parameter platform for use in autoimmune diseases – technical aspects and first results on ANA testing
I. Abreu, H. Guimaraes, A. Bastos, V. Pato, F. Barcelos, G. Sousa, H. Trindade: Evaluation of ANA-ENA antibodies in sera of patients with Sjögren’s syndrome using two multiplexed immunoassays (AtheNA multi-lyte ana system and the FIDISTM connective) and two conventional methods (Ouchterlony double immunodiffusion, immunoblotting)
N. Bardin, S. Desplat-Jego, B. Larida, M. Sanmarco: BioPlex™2200 system: Simultaneous detection of anti-dsDNA and anti-nucleosome antibodies in patients with systemic lupus erythematosus
T. Witte, J. Smith, D. Mosedale, R. E. Schmidt: Comparison between UltraPlex™ barcoded microparticle technology and enzyme-linked immunosorbent assay for the determination of antibodies to dsDNA and extractable nuclear antigens
A. Kozmar, M. Rudolf, I. Radic, B. Malenica: Evaluation of multiplexed fluorescence microsphere immunoassay for detection of autoantibodies to nuclear antigens
W. Meyer, T. Scheper, N. Janssen, S. Torkler, W. Schlumberger, W. Stöcker: EUROLINE Myositis Profile: A newly developed line immunoassay for the detection of myositis specific autoantibodies
K. Großmann, U. Wagner, R. Hiemann, S. Milius, E. Kalz, T. Büttner, K. Conrad, W. Lehmann: Microblots for autoantibody differentiation
9.3
Improvement of Autoantibody Detection
C. Probst, L. Komorowski, C. Dähnrich, A. Rosemann, W. Schlumberger, K.-P. Wandinger, T. Mothes, W. Stöcker: Designer antigens as diagnostic targets for (auto)antibody determination
J. Michel, R. Hiemann, N. Hilger, K. Kaltschmidt, M. Weigert, U. Sack, U. Anderer: HEp-2 cell preparation for automated analysis of autoantibodies
R. Hiemann, N. Hilger, K. Conrad, D. Roggenbuck, J. Michel, U. Anderer, M. Weigert, U. Sack: Autoantibody screening by indirect immunofluorescence on HEp-2 cells: Comparison of a novel automated image processing with visual examination
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