B. W. Urban, M. Barann (Eds.)
Molecular and Basic Mechanisms of Anesthesia

• M. Barann, K. W. Miller, C. D. Richards, S. H. Roth, B. W. Urban: Preface: Molecular and Basic Mechanisms of Anesthesia

• G. S. Bause: Bernard Raymond Fink, M.D., F.F.A.R.C.S. (1914-2000)

1. Molecular Basis of Anesthetic Interactions

• J. R. Trudell, E. Bertaccini: Molecular Modelling of Anesthetic Binding Sites in Ligand-Gated Ion Channels

• J. S. Johansson, G. A. Manderson: The Effect of Aromatic Amino Acid Side-Chain Structure on Halothane Binding to Four-Helix Bundles

• Y. Kaminoh, C. Tashiro, H. Kamaya: The Interaction of Local Anesthetics with the DMPG Membrane

• K. Ogli: Halothane Decreases the Viscosity of Bovine Serum Albumin (BSA) Solution

• Abstracts

• E. A. Barnard: The Range of Channel Structures and Their Potential Sites for Anesthetic Interaction

• J. P. Dilger, D. Oustecky, C. J. Tzan: Kinetics Count! Examples Using the Acetylcholine Receptor

• E. I. Eger II: What Have We Learned from Nonimmobilizers?

• M. Jetzek-Zader, P. Lipfert: Characterisation of Anesthetic Target Sites by Fluorescence: Acridine and Methyl Salicylate Have Anesthetic Properties and Interact with Albumin and Octanol

• C. Sándorfy: Towards a Comprehensive Theory of General Anesthesia

• Abstracts

2. Anesthetic Interactions with Ion Channels and Other Proteins

• H. R. Arias, E. A. McCardy, M. J. Gallagher, M. P. Blanton: A Barbiturate Binding Site in the Nicotinic Acetylcholine Receptor Ion Channel

• P. Flood, J. M. Sonner: Behavioral Results of Isoflurane Inhibition of Neuronal Nicotinic Acetylcholine Receptors

• P. Friederich, A. Dybek, M. Barann, B. W. Urban: SH-SY5Y cells: A Model for the Study of Pharmacological Action on Human Nicotinic Acetylcholine Receptors of Sympathetic Ganglions

• T. Narahashi, J. Z. Yeh, T. Mori, G. L. Aistrup, W. Marszalec, Y. Zuo, X. Zhao: Role of Neuronal Nicotinic Acetylcholine Receptors in the Mechanism of General Anesthesia

• T. Narahashi, J. Z. Yeh, G. L. Aistrup, Y. Zuo, W. Marzalec : Modulation of Neuronal Nicotinic Acetylcholine Receptors by Alcohols

• R. J. Claycomb, S. A. Forman, D. E. Raines : Inhibition of a₄b₂ Rat Neuronal Nicotinic Acetylcholine Receptors by Nonhalogenated Alkane Anesthetics and Perhalogenated Alkane Nonimmobilizers

• I. Wenningmann, D. Demazumder, J. P. Dilger: The Kinetics of Inhibition of Nicotinic Acetylcholine Receptors by Metocurine

• Abstracts

• M. H. Akabas, J. Horenstein, D. B. Williams, M. Bali, A. K. Bera: GABA- and Drug-Induced Conformational Changes Detected in the GABA_A Receptor Channel-Lining Segments

• G. Akk, J. H. Steinbach: Do Barbiturates Affect How GABA_A Receptors Open or How They Close?

• G. Haeseler, B. Mohammadi, K. Krampfl, M. Leuwer, R. Dengler, S. Piepenbrock, J. Bufler: The Potency of a Phenol Derivative for Direct Activation of Chloride Currents via GABA_A Receptors is Related to the Position of Methyl and Isopropyl Groups with Respect to the Phenolic Hydroxyl Group

• Abstracts

• M. Barann, B. W. Urban: Anesthetic Actions on 5-HT₃ Receptors: Separate Access Routes and Separate Mechanisms?

• R. A. Harris, M. P. Mascia, I. A. Lobo: Sites of Anesthetic Action on a Ligand-Gated Ion Channel

• Abstracts

• Z. J. Bosnjak : Anesthetic-Induced Cardiac Preconditioning

• M. Gruß, M. Henrich, P. König, G. Hempelmann, W. Vogel, A. Scholz: Ethanol Modifies Action Potentials in a Subtype of Small Sensory Neurones by Activation of BK_Ca-Channels

• L. G. Weigl, H. Kress, W. Schreibmayer: G Protein Gated Inwardly Rectifying Potassium Channels Are Targets for Volatile Anesthetics

• C. S. Yost, C. H. Kindler: Tandem Pore (2P) Domain K⁺ Channels as Anesthetic Targets

• Abstracts

• M. D. Baker: Function and Local Anesthetic Block of Late Na⁺ Current in Sensory Neurones

• G. L. McKinney, J. A. Harris, R. P. Burton, R. B. Fisher, G. R. Kracke: Inhibition of Cyclic Nucleotide-Gated Ion Channels by the Local Anesthetics Mexiletine and Lidocaine

• C. Nau, S. Y. Wang, G. K. Wang: Involvement of Sodium Channel Transmembrane Segments S6 in Local Anesthetic Binding

• A. Scholz: Blockade of TTX-Resistant Na⁺ Currents by Local Anesthetics: Functional Impact in Sensory Neurones

• S. K. W. Schwarz, E. Puil: CNS Effects of Local Anesthetics: Novel Lidocaine Actions in the Thalamus

• Abstracts

• C. Hönemann, S. Berning, B. Linck, K. Hahnenkamp, J. Nollet, H. van Aken: Inhibitory Effect of Bupivacaine on Lysophosphatidate (LPA) Signaling – An Alternativ Mechanism: Stimulation of Protein Phosphatases (PP)?

• M. Maze: Adrenergic Receptors Are Sites for the Analgesic Response to General Anesthetics

• P. Nagele, W. J. Placzek, C. M. Crowder: Isoflurane Binds to Presynaptic SNARE Proteins

• J. Nollet, K. Hahnenkamp, S. Sertel, T. Podranski, S. Berning, H. van Aken, E. Mortier, M. E. Durieux, C. W. Hönemann: Effect of Volatile and Local Anesthetics on PGE₂ and TXA₂ Receptors

• S. Wittmann, S. Daniels, D. Fröhlich: Thiopentone and Propofol Inhibit the Expression of FMLP Receptors in Human Neutrophils in Vitro

• Abstracts

3. Integration of Anesthetic Actions (In-Vitro)

• S. Baudoux, R. M. Empson, C. D. Richards: General Anesthetics Do Not Prevent Action Potential Invasion of Axon Branches or Synaptic Boutons

• H. C. Hemmings Jr., W. OuYang, R. I. Westphalen: Presynaptic Targets for General Anesthetics

• C. H. Kindler: Nonimmobilizers Do Not Cause Muscle Contractures in Patients Susceptible to Malignant Hyperthermia

• M. C. Moe, J. Berg-Johnsen, M. L. Vinje: The Effect of Isoflurane and Sevoflurane on Presynaptic Protein Kinase C Activity

• B. A. Orser, D. T. Joo, G. Zhu, J. Roder, M. F. Jackson, Z.-P. Jia, J. F. MacDonald: Increased Desensitization of AMPA Receptors May Cause Hypersensitivity to Anesthetics in GluR2 Null Mutant Mice

• M. Perouansky: Anesthetic Targets on the Glutamatergic Terminal – Why Bother?

• C. Stößel, P. W. L. Tas, N. Roewer: Inhibition of the Capacitative Ca²⁺-Entry of Primary Endothelial Cells by Volatile Anesthetics

• W. Zink, B. M. Graf, E. Martin, R. H. A. Fink, G. Kunst: Modulation of Intracellular Calcium Homeostasis by Tetracaine in Skinned Skeletal Muscle Fibres – Reasons for Its Moderate Myotoxicity?

• Abstracts

• T. Asahi, K. Hirota, R. Sasaki, M. Yamazaki: Effects of Volatile Anesthetics, n-Alcohols and Ketamine on Synaptic and Non-Synaptic Pathways in Rat Hippocampal Slices in Vitro

• C. Benkwitz, N. Roewer, B. Antkowiak: Anesthetic Action on Neuronal Network Activity in Hippocampus: Electrophysiology and Ca-Imaging

• C. Grasshoff, B. Antkowiak: Effects of Volatile Anesthetics on Action Potential Firing of Spinal Neurons in Organotypic Slice Cultures

• K. Hirota, T. Asahi, R. Sasaki, M. Yamazaki, S. H. Roth: The Agent- and Pathway-Specific Actions of General Anesthetics in Hippocampus in Vitro

• J. Kendig: Anesthetic Actions on the Spinal Cord in Vitro

• S. H. Roth, N. Samanani, D. P. Archer: Receptor-Mediated Excitatory Effects of General Anesthetics

• R. Sasaki, K. Hirota, M. Yamazaki: Barbiturates Accelerate the Recovery from Brief Hypoxia in Area CA1 of Rat Hippocampal Slices

• Abstracts

• U. Guenther, A. M. Bischoff, D. Kettler, D. W. Richter: 5-HT_1A-Agonists Protect Against Opioidergic Depression of Respiration

• S. Pentyala, J. Halpern-Lewis, An. Sawas, D. Rosa, Ay. Sawas, M. Rebecchi, S. Vitkun: Intravenous Anesthetics Reduce Airway Resistance by Their Action on Plasma Membrane Calcium Pump

• P. W. L. Tas, C. Eisemann, N. Roewer: The Volatile Anesthetic Halothane Suppresses Spontaneous Calcium Oscillations in Hippocampal Neurons by Activation of Adenosine A1 Receptors

• Abstracts

4. In-Vivo-Networks

• W. Heinke, C. Schwarzbauer: Subanesthetic Isoflurane Affects Task-Induced Brain Activation in a Highly Specific Manner: A Functional Magnetic Resonance Imaging Study

• P. Jakubow, J. J. Braszko: The Effect of Propofol on Short Term Memory After Anesthesia

• S. Nishimura, S. Yokono, N. Taenaka, T. Mashimo: General Anesthesia Suppresses Nocturnal Melatonin Secretion

• B. Rehberg, T. Kammer, H. C. Wartenberg, I. Wenningmann, B. W. Urban: Effects of Sevoflurane and Propofol on the Human Motor System

• R. A. Veselis, R. A. Reinsel, V. A. Feshchenko: Novel Insights into Drug – Memory Interactions Using Functional Neuroimaging (FNI) Techniques

• Abstracts

• A. Angel: Oscillations in an Apparent Steady-State of Anesthesia

• A. Angel: Effects of Xenon on Somatosensory Transmission in the Rat

• J. F. Antognini, E. Carstens: Spinal Cord Actions of Halothane, Thiopental and Isoflurane

• J. F. Antognini, E. Carstens, M. Sudo, S. Sudo: Thiopental Directly Depresses Lumbar Dorsal Horn Neurons in Goats

• O. Detsch, W. Reeker, M. Siemers, E. Kochs, B. Bromm, C. Vahle-Hinz: Suppression of Tactile Information Transfer by Isoflurane Within the Central Nervous System

• S. Gamo, A. Tamai, I. Hotta, T. Koma, Y. Tanaka: A Possible Anesthetic Pathway of Diethylether Derived from Drosophila Mutants

• H. Nakao, T. Uefuji, N. Miyashita: Enflurane Sensitivities of Mice May depend on the Color of the Fur

• J. M. Sonner: GABA_A Receptors Contribute Minimally to Isoflurane MAC

• P. H. Tonner: Does the NO/cGMP Signal Transduction Pathway Mediate the Action of General Anesthetics?

• C. Vahle-Hinz, W. Reeker, O. Detsch, M. Siemers, E. Kochs, B. Bromm: Antinociceptive Effects of Anesthetics in Vivo: Thalamic Neuronal Responses and Cellular Mechanisms

• Abstracts

• E. I. Eger II: Anesthesia Produced by Inhaled Anesthetics Is an Immediately Reversible State Mediated by the Central Nervous System that Consists of Amnesia and Immobility in the Face of Noxious Stimulation

• T. Engelhardt, H. F. Galley, F. M. MacLennan, N. R. Webster: Changes of Saliva Cyclic GMP in Healthy Volunteers and Patients Undergoing General Anesthesia

• C. Lynch III: MAC - A Clinical Point of View

• J. M. Sonner: Population Variability in MAC: What Is It and What Does It Mean?

• M. Bleckwenn, B. W. Urban: Is the Meyer-Overton Correlation Still Relevant?

• Abstracts

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